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The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Experimental Days
Methacholine was mixed with 500 MBq “mTc-DTPA and diluted with saline solution to reach the intended concentration of methacholine and a final volume of 3 ml. The relationship between the amount of radioactivity and methacholine was fixed for each individual in the two experiments. The aerosol was inhaled by tidal breathing, which was maintained during […]
The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Material and Methods
Five female and three male subjects (mean age, 34 ±8 years) with proved bronchial hyperresponsiveness to inhaled methacholine participated in the study. The patients had a clinical diagnosis of bronchial asthma, and their baseline value of forced expiratory volume in 1 s (FEVi) was at least 80 percent of predicted normal value, and the upper […]
The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern
Asthma is characterized by increased bronchial responsiveness to a variety of pharmacologic and immunologic stimuli of the bronchial mucosa. Bronchial responsiveness to inhaled parasympathomimetic agents, eg, methacholine, is used in clinical settings to estimate the intensity of the asthmatic process. Stimulation of muscarinic receptors on airway smooth muscle cells and submucosal glands induces airway muscle […]