Archives - Part 2
The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Discussion
The responses also tended to be more protracted than after the central airway deposition of methacholine, and in contrast to the findings after central airway deposition, the decrement of sGaw relative to baseline remained statistically significant (p<0.05) 30 min after the challenge. The three patients who had subnormal sGaw at baseline tended to have a […]
The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Results
The sGaw values tended to return to the baseline within 30 min. However, the bronchocon-striction tended to remain during a longer time period in the three patients who had subnormal baseline values lie, <1.3 [sxkPa]); their mean value of sGaw remained at 27 ±9 percent of baseline (mean±SD), while in those who had normal baseline […]
The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Results
The data were expressed by mean values and SD. The statistical analyses used were Mann-Whitney U test, Wilcoxon matched-paired test, and Spearmans correlation test. A p value of <0.05 was considered to indicate statistical significance. Baseline Conditions on the Two Experimental Days Before challenge, sGaw was within the predicted normal values in five of the […]
The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Radionuclide Imaging
The radioactivity deposited in the lungs was recorded by means of a gamma-camera (Picker SX300, Nuclear Diagnostics, United States). Data were recorded in a 64X64 matrix, and the total activity as well as counts per pixel were recorded in areas corresponding to the lung fields. Regions of interest were defined and selected from the stored […]
The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Experimental Days
Methacholine was mixed with 500 MBq “mTc-DTPA and diluted with saline solution to reach the intended concentration of methacholine and a final volume of 3 ml. The relationship between the amount of radioactivity and methacholine was fixed for each individual in the two experiments. The aerosol was inhaled by tidal breathing, which was maintained during […]
The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Material and Methods
Five female and three male subjects (mean age, 34 ±8 years) with proved bronchial hyperresponsiveness to inhaled methacholine participated in the study. The patients had a clinical diagnosis of bronchial asthma, and their baseline value of forced expiratory volume in 1 s (FEVi) was at least 80 percent of predicted normal value, and the upper […]
The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern
Asthma is characterized by increased bronchial responsiveness to a variety of pharmacologic and immunologic stimuli of the bronchial mucosa. Bronchial responsiveness to inhaled parasympathomimetic agents, eg, methacholine, is used in clinical settings to estimate the intensity of the asthmatic process. Stimulation of muscarinic receptors on airway smooth muscle cells and submucosal glands induces airway muscle […]