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The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients: Finally

Posted in April 10th, 2014

The role of worsening diaphragmatic weakness as an acute cause of failure to wean from mechanical ventilation is not well defined. Several reviews have concluded that inspiratory muscle weakness may predispose to acute respiratory failure or complicate weaning from mechanical ventilation. The corollary of this would be that treatment aimed at improving respiratory muscle strength […]

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The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients: Conclusion

Posted in April 8th, 2014

The unknown extent of carryover of the effects of magnesium, therefore, limited the application of the crossover design in our data analysis. We therefore only analyzed our results from the period before infusion to that immediately following infusion of magnesium. Using this analysis, if we reject the hypothesis of a subgroup of patients and accept […]

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The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients: Discussion

Posted in April 6th, 2014

Molloy and associates had evaluated the effects of hypomagnesemia on respiratory muscle strength in 11 patients admitted to the hospital for treatment of alcohol withdrawal and in 6 patients with chronic obstructive pulmonary disease. They found that infusion of 6 g of magnesium increased PEmax by 24 percent and Pimax by 46 percent. Fiaccadori and […]

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The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients: Results

Posted in April 4th, 2014

We completed 21 separate studies on a total of 20 patients admitted to our ICU. One patient was included twice for two separate episodes of respiratory failure. The average age was 59 years (range, 22 to 84 years) and there were 14 men and 6 women. The admitting diagnoses to ICU were as follows: eight […]

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The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients: Materials and Methods

Posted in April 2nd, 2014

Subjects We studied 20 patients admitted to our medical-surgical ICU. All patients requiring mechanical ventilation for more than 3 days were eligible for study. Exclusion criteria included the following: (1) hemodynamic instability’; (2) chest wall instability; (3) preexisting renal failure (creatinine >200 mmol/L); (4) atrioventricular conduction defects; and (5) inability to give informed consent. Patients […]

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The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients

Posted in March 31st, 2014

Therapy directed toward improving respiratory muscle strength has been advocated for patients with respiratory muscle weakness and respiratory failure once their conditions have been stabilized by initiation of mechanical ventilation. Along with malnutrition, hypomagnesemia is a recognized cause of both skeletal muscle weakness and of respiratory muscle weakness. Patients with chronic obstructive pulmonary disease admitted […]

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Outcome of Patients Requiring Medical ICU Admission Following Bone Marrow Transplantation: Conclusion

Posted in March 29th, 2014
Published in ICU

While clearly related to prognostic score at the time of admission, the development of MOF during MICU hospitalization was also an important predictor of death. A number of studies have demonstrated a relationship between MOF and death in the ICU. Of the 24 nonsurvivors, all but 4 developed MOF during their MICU stay. All three […]

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