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The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Conclusion

Posted in September 21st, 2014
Published in Pulmonary Function

Theoretically, differences in regional deposition of a vasoactive drug might then elicit different responses or time courses of effects, dependent on the deposition pattern. Experimental studies have suggested that a compound may be rapidly redistributed throughout the lung by bronchial blood flow This ability may have a role in airway homeostasis by enhancing the clearance […]

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The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Conclusion

Posted in September 20th, 2014
Published in Pulmonary Function

Similarly, collateral ventilation may also be more effective at a segmental level than when a whole lobe is obstructed, at least in the dog Our findings further support the previously reported discrepancy in time courses of Va/Q mismatch and bronchial constriction, and the discrepancy occurred independently of whether the aerosol was deposited in the central […]

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The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Comment

Posted in September 19th, 2014
Published in Pulmonary Function

Similar to the conditions reported there, we postulated that mixing of the two water-soluble compounds, methacholine and DTPA, was homogeneous, both in the nebulizing chamber and in the separate aerosol particles. We, therefore, assumed that the differences in amounts of methacholine deposited within the various sections of the airways were proportional to the differences in […]

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The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Discussion

Posted in September 18th, 2014
Published in Pulmonary Function

The responses also tended to be more protracted than after the central airway deposition of methacholine, and in contrast to the findings after central airway deposition, the decrement of sGaw relative to baseline remained statistically significant (p<0.05) 30 min after the challenge. The three patients who had subnormal sGaw at baseline tended to have a […]

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The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Results

Posted in September 17th, 2014
Published in Pulmonary Function

The sGaw values tended to return to the baseline within 30 min. However, the bronchocon-striction tended to remain during a longer time period in the three patients who had subnormal baseline values lie, <1.3 [sxkPa]); their mean value of sGaw remained at 27 ±9 percent of baseline (mean±SD), while in those who had normal baseline […]

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The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Results

Posted in September 16th, 2014
Published in Pulmonary Function

The data were expressed by mean values and SD. The statistical analyses used were Mann-Whitney U test, Wilcoxon matched-paired test, and Spearmans correlation test. A p value of <0.05 was considered to indicate statistical significance. Baseline Conditions on the Two Experimental Days Before challenge, sGaw was within the predicted normal values in five of the […]

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The Bronchial Response, but not the Pulmonary Response to Inhaled Methacholine Is Dependent on the Aerosol Deposition Pattern: Radionuclide Imaging

Posted in September 15th, 2014
Published in Pulmonary Function

The radioactivity deposited in the lungs was recorded by means of a gamma-camera (Picker SX300, Nuclear Diagnostics, United States). Data were recorded in a 64X64 matrix, and the total activity as well as counts per pixel were recorded in areas corresponding to the lung fields. Regions of interest were defined and selected from the stored […]

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