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Persistence of Airway Obstruction and Hyperresponsiveness in Subjects With Asthma Remission: Respiratory Symptoms
On initial questionnaire, 29 asthmatics “in remission” (15 controls) described occasional respiratory symptoms following either allergen exposure (n=15, 6 controls), viral infections, or exposure to different conditions or stimuli (humidity, cold air, smoke, heavy exercise). During the 14-day period of PEFR measurement and symptoms recordings, 12 “ex-asthmatics” (one control) had symptoms such as either dyspnea, […]
Persistence of Airway Obstruction and Hyperresponsiveness in Subjects With Asthma Remission: Response to Bronchodilators
In asthmatics “in remission,” improvement in FEVi following bronchodilator was small although larger than in controls, with a percent change from baseline values ranging from —1.1 to 14.1 percent; mean, 5.7 ±0.8 percent (controls: —4.4 to 10.5 percent; mean, 2.5 ±0.6 percent; p=0.004). After 200 fig of inhaled albuterol, FEF25-75% increased 2.2 to 50 percent […]
Persistence of Airway Obstruction and Hyperresponsiveness in Subjects With Asthma Remission: Results
Results were similar whether the five hyperreactive subjects were replaced or not, except for bronchodilator response, as commented in this section. Therefore, the results presented are those of the 30 ex-asthmatics in comparison to the 30 initial controls, including these 5 hyperreactive subjects. Our subjects reported no symptom attributed to asthma or any need for […]
Persistence of Airway Obstruction and Hyperresponsiveness in Subjects With Asthma Remission: Statistical Analysis
Study Design The subjects came to the laboratory on three different occasions. On the first visit, one of the investigators administered a questionnaire on the characteristics of their former asthma (duration, severity, medication requirements, potential initiating factors, time of asthma diagnosis and of remission, including last 2 years’ respiratory symptoms, and family history of asthma). […]
Persistence of Airway Obstruction and Hyperresponsiveness in Subjects With Asthma Remission: Methods
Subjects Sixty-five subjects took part in this study (Table 1). Of these, 30 ex-asthmatics were recruited from advertisements in different media. Inclusion Criteria and Definition of Asthma Remission We included in the study men or women >18 years old, atopic or not, with a proven history of asthma responding to the American Thoracic Society criteria, […]
Persistence of Airway Obstruction and Hyperresponsiveness in Subjects With Asthma Remission
Bronchial asthma is characterized by variable airflow obstruction and airway hyperresponsiveness. Its underlying mechanism is considered to be an airway inflammatory process with bronchial epithelial damage and mucus secretion, and in which eosinophils and lymphocytes seem to play a key role.2 There is still no cure for asthma. We may, however, observe remissions, either spontaneously, […]
Comparison of Four Methods for Calculating Diffusing Capacity by the Single Breath Method: Conclusion
Our results with the 3PIT method can be only loosely compared with results of Graham et al who documented the differences in Deo using Og, JM, ESP, and three-equation methods in patients with emphysema, asthma, and cystic fibrosis. For both Og and JM methods, Graham et al allowed a 1-L dead space washout volume and […]