Archives - Part 2
The Third Epidemic—Multidrug-Resistant Tuberculosis: Discussion
During the past decade, the incidences of HIV infection and ТВ have ascended to epidemic proportions in several major US cities. At Bellevue Hospital Center in Manhattan, the incidence of MDR-TB has increased sevenfold in 1991 as compared with any of the previous 20 years. buy antibiotics online Several case series have been reported by […]
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The Third Epidemic—Multidrug-Resistant Tuberculosis: Results
We analyzed the drug susceptibilities of 4,681 cases of ТВ from 1971 to 1991 at Bellevue Hospital Center, finding a dramatic increase in MDR-TB (isoniazid plus rifampin) in 1991 (Fig 1). There was an increase from a baseline of 2.5 to 16 percent combined isoniazid plus rifampin resistance in 1991. Among the 224 positive initial […]
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The Third Epidemic—Multidrug-Resistant Tuberculosis: Methods
The reported incidence of tuberculosis (ТВ) declined for decades in the United States reaching a nadir of 22,255 cases in 1984, but then leveled off and began to rise. During the period from 1985 to 1991, approximately 39,000 excess cases occurred over and above the expected number. This alarming reversal of the downward trend in […]
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The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients: Finally
The role of worsening diaphragmatic weakness as an acute cause of failure to wean from mechanical ventilation is not well defined. Several reviews have concluded that inspiratory muscle weakness may predispose to acute respiratory failure or complicate weaning from mechanical ventilation. The corollary of this would be that treatment aimed at improving respiratory muscle strength […]
The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients: Conclusion
The unknown extent of carryover of the effects of magnesium, therefore, limited the application of the crossover design in our data analysis. We therefore only analyzed our results from the period before infusion to that immediately following infusion of magnesium. Using this analysis, if we reject the hypothesis of a subgroup of patients and accept […]
The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients: Discussion
Molloy and associates had evaluated the effects of hypomagnesemia on respiratory muscle strength in 11 patients admitted to the hospital for treatment of alcohol withdrawal and in 6 patients with chronic obstructive pulmonary disease. They found that infusion of 6 g of magnesium increased PEmax by 24 percent and Pimax by 46 percent. Fiaccadori and […]
The Lack of Effect of Routine Magnesium Administration on Respiratory Function in Mechanically Ventilated Patients: Results
We completed 21 separate studies on a total of 20 patients admitted to our ICU. One patient was included twice for two separate episodes of respiratory failure. The average age was 59 years (range, 22 to 84 years) and there were 14 men and 6 women. The admitting diagnoses to ICU were as follows: eight […]