Archives - Part 2
Pulmonary Mycobacterium kansasii Infection in Israel, 1999-2004: Statistical Analysis
Data on clinical features of the patients (including systemic comorbid disease and smoking status), radiologic findings, treatment, and outcome were obtained from the case notes and laboratory records by a single investigator. Chest radiographs obtained within 2 weeks of diagnosis of mycobacterial disease were read by an independent investigator who was blinded to the clinical […]
Pulmonary Mycobacterium kansasii Infection in Israel, 1999-2004: Materials and Methods
The study sample included 56 patients with a diagnosis of M kansasii lung infection who attended the tuberculosis centers in Tel Aviv and Rehovot, Israel, from April 1999 to April 2004. The diagnosis was based on the guidelines of the ATS, namely appropriate symptomatology, compatible radiographic abnormalities, and multiple culture-positive respiratory specimens for M kansasii.15 […]
Pulmonary Mycobacterium kansasii Infection in Israel, 1999-2004
Mycobacterium kansasii has traditionally been considered the most virulent of the nontuber-culous mycobacteria.,2 It is the second most common nontuberculous mycobacterium after Mycobacterium avium complex3 and the most common cause of nontuberculous mycobacterial lung disease in the United Kingdom and Western Europe. Infection with M kansasii probably occurs via an aerosol route, Tap water is […]
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Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Study Limitations
We only investigated the role of a single-nucleotide polymorphism (SNP) on physiologic function. Previous work by Drysdale and colleagues sequenced the entire P2AR in a large population of asthmatics. They subsequently grouped the SNPs according to haplotypes; and while no SNP was associated with response to a P-agonist, combinations of SNPs grouped according to haplotype […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Conclusion
Interestingly, the difference between the Arg16 and Gly16 genotypes in FEF50 occurred during a time when catecholamines were rapidly returning to baseline after the airway P2ARs had been exposed to catecholamines for 10 to 15 min (exercise plus early cool down). This may suggest that significant in vivo desensitization takes between 9 min and 15 […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Discussion
The coding region of the P2AR demonstrates multiple sites of polymorphic variation such as positions 16, 27, and 164. Positions 16 and 27 have been studied extensively both in vitro and in oioo. In vitro, the most impaired polymorphic receptor appears to be due to a threonine to isoleucine change at amino acid 164. However, […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Airway Responses to Exercise
The focus of our study was to examine the influence of variation in the P2AR gene at codon 16 on the airway responses to exercise in young, healthy adults. We found that the degree of bronchodilation with light- and heavy-intensity exercise was similar between the homozygous Arg16 and Gly16 subjects. However, during the recovery period, […]