Archives - Part 3
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Catecholamine Response to Exercise
Figure 1 shows the changes in arterial levels of epinephrine and norepinephrine during low- and high-intensity exercise as well as during recovery (expressed as the percentage change from rest). No significant differences were observed between groups, although the Arg16 subjects tended to have a greater increase in epinephrine than the Gly16 subjects (p = 0.07). […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Subject Characteristics
The demographic data were examined using independent t tests with an a = 0.05. We used analysis of variance to examine differences in the primary outcome measure, FEF50 (SPSS; Chicago, IL). An analysis of covariance was also performed between the groups with epinephrine as the covariate and FEF50 as the dependent variable. Prior to beginning […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Data Collection
Cardiopulmonary Assessment During Exercise: Measurements of oxygen uptake (Vo2) and the elimination of carbon dioxide were measured continuously during the various exercise tests and stages using a metabolic cart (Medical Graphics; St. Paul, MN) interfaced with a mass spectrometer (Perkin Elmer; Wellesley, MA). This system has been validated against classic “bag” collection techniques, and stability […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Data Collection
The next session consisted of a cycle ergometry test similar to the first visit. However, during this second study, classical gas exchange measures were collected and subjects also were instructed to perform maximal expiratory flow volume (MEFV) maneuvers at rest and over the last 30 s of each work level (every 2 min). Since most […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Materials and Methods
These differences were not observed in children, suggesting the Arg16Gly polymorphism may influence the rate of decline in lung function with aging. The focus of the present study was to determine if common polymorphisms of the (P2AR differentially influence airway tone during and after short-term exercise in healthy subjects without asthma. We hypothesized that subjects […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults
The respiratory system adapts to changes in metabolic demand in an attempt to maintain gas exchange homeostasis at minimal cost. Among the many respiratory adaptations that occur during exercise is exercise-induced bronchodilation, the mechanism of which remains controversial.’2 Changes in airway tone with exercise, although small, are important, as it allows for a large increase […]
Diffusing Capacity for Nitric Oxide and Carbon Monoxide in Patients With Diffuse Parenchymal Lung Disease and Pulmonary Arterial Hypertension: Recommendation
An interesting study was performed by Bonay et al, who investigated whether the Vcap (determined with the single-breath high/low oxygen method) would be lower in subjects with DPLD and associated PAH than in subjects with DPLD without PAH. This appeared not to be the case, thus excluding the Vcap measurement as a screening test for […]