Latest News - Part 40

Which one works better, Viagra, Levitra, or Cialis?

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Which one works better?

Viagra, Levitra, and Cialis are all three excellent medications that have dramatically improved millions of men’s life. Although all three drugs essentially function in the same way, they are chemically different and can affect each person differently.

The differences between generic Viagra, generic Levitra, and generic Cialis have to do with:
– how fast does the medication start working?
– how long does it stay active in your body?
– what if any side effects do you experience and to what degree?

Canadian Viagra has been around the longest, and therefore has a better safety and efficacy profile, maintained by the numerous studies as well as real-world experience.

Levitra and Cialis are both more targeted drugs than generic Viagra, therefore, it takes a smaller dose of Levitra or Cialis to achieve the same effect as Viagra:

Levitra drugs and Cialis drugs are very selective in attacking PDE-5 without affecting other isoenzymes (more targeted), therefore the smaller 10mg average dose of Levitra or Cialis has the same results as the larger 50mg average Viagra dose, even though the three drugs essentially function the same way.

Cheap Viagra is very fast-acting as it takes effect in about only 30 minutes for most men, and the effects last for 4 hours or more.

Canadian Levitra is also fast-acting as it generally takes effect in about 30 to 60 minutes for most men, and it stays active in your body for up to 4 hours.

Canadian Cialis on the other hand is slow-acting, reaching maximum concentration in about 2 hours for most men, and long-lasting, staying active in the body for up to 36 hours.

Most importantly, the answer to this question depends on how well your body responds to each brand. You might be satisfied with any of the three brands and not notice a difference. On the other hand, one brand might produce better erection results for you, but at the same time might bother you with a side effect. Similarly, the erection you got from taking one brand was not that good or didn’t last as long compared to the other brand, but at least it was free of side effects.

The best is therefore to experiment with each brand and find out which one your body responds best to. It is however not safe to take two different brands together at the same time. Try all three, but on different occasions.

Also, it is a good idea to get a full physical examination before trying any of these medications, to first find out the cause of your ED, and make sure you are healthy enough for sexual activity. Your ED may be caused by another medication you are currently taking, or it may be resolved by your doctor without having to resort to medication.

Another difference between Viagra, Levitra, and Cialis, might be cost, although the price differences are usually small. The most cost effective way to buy these medications is to buy the maximum dose available (100 mg for Viagra, 20mg for Levitra, 20mg for Cialis), and use a pill-cutter to split the pills in half.

What other precautions should I take when using Cialis?

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precautions

Before using Cialis (Tadalafil), tell your doctor your medical history, including any allergies (especially drug allergies), any penis conditions such as fibrosis/scarring (e.g., Peyronie’s disease), history of painful/prolonged erection (priapism), sickle cell anemia, blood system cancers (such as leukemia or myeloma), eye problems (retinal diseases), kidney or liver disease, bleeding disorders or active stomach ulcers, heart diseases, stroke or severe high or low blood pressure.

Cialis should not be taken simultaneously with other ED treatments.

Limit alcohol intake, as it may aggravate side effects of Cialis. Since this drug may cause dizziness, caution is advised when performing tasks requiring alertness (e.g., driving). To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly.

Also, eventhough what you eat has very little effect on Cialis, it is still advised to avoid eating grapefruits or drinking grapefruit juice while taking generic Cialis. Cialis drug is metabolized predominently by the hepatic enzyme known as CYP3A4. Grapefruit juice is an inhibitor of this CYP3A4 enzyme, and can therefore interfere with the normal breakdown process of the medication, leading first, to delays in absorption of Cialis, and second, to the prolonged, unnecessary, and potentially harmful presence of the drug in your body.

Cialis is not to be used in women or children. Older men may be more sensitive to the side effects of this drug, therefore caution is advised.

It’s important to tell your doctor about any medicines you take, both prescription and nonprescription. A medicine you are taking for another health problem might be causing your ED. Talk with your doctor about the medicines you are taking. And never stop taking any medicine before talking to your doctor.

Do not share Cialis with others, since they may have a problem that is not effectively treated by this drug. Worse yet, sharing with someone who should not take Cialis may put their health and life at risk. They may be taking other drugs and this could create adverse drug interactions.

Canadian Cialis does not protect against sexually transmitted diseases (e.g., HIV, Hepatitis B, gonorrhea). Remember to protect yourself and your partner from sexually transmitted diseases.

What are the possible drug interactions of Cialis?

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drug-interaction

Inform your healthcare provider, during either a physical or online consultation, about all prescription and non-prescription medications you use, especially any nitrate medications (e.g., nitroglycerin, isosorbide dinitrate), nitroprusside (any “nitric oxide donor” medicines), cimetidine, erythromycin, azole antifungals (e.g., itraconazole, ketoconazole pills), mibefradil, rifamycins (e.g., rifampin), high blood pressure medicines, alpha-blockers, or HIV protease inhibitors. Do not start or stop any medicine without your healthcare provider’s approval.

If you are taking certain alpha-blockers for the treatment of heart disease, such as Hytrin (terazosin) or Flomox (tamsulosin), or if you are taking certain protease inhibitors for the treatment of HIV, such as saquinavir, ritonavir, or amprenavir, it is recommended not to exceed a maximum single dose of 2.5 mg of Cialis in a 72-hour period, because the combination of Canadian Cialis with such drugs may lower blood pressure to an unsafe or life-threatening level. Be sure to consult your healthcare provider about this.

If you are taking azole antifungals (such as ketoconazole or itraconazole), it is recommended not to exceed a maximum single dose of 5 mg of Cialis in a 24-hour period.

Cialis is not recommended for people taking commonly prescribed short and long-acting nitrates because the combination may lower blood pressure.

Commonly prescribed short and long-acting nitrates available in the US are: Nitroglycerin, Deponit, Minitran, Nitrek, Nitro-Bid, Nitrocine, Nitro-Derm, Nitro Disc, Nitro-Dur, Nitrogard, Nitroglycerin, Nitroglycerin T/R, Nitroglyn, Nitrol Ointment, Nitrolan, Nitrolingual Spray, Nitrong, Nitropar, Nitropress, Nitroprex, Nitro S.A., Nitrospan, Nitrostat, Nitro-Trans System, Nitro Transdermal, Nitro-Time, Transderm-Nitro, Tridil, Isosorbide Mononitrate, Imdur, ISMO, Isosorbide Mononitrate, Monoket, Isosorbide Nitrate, Dilatrate-SR, Iso-bid, Isordil, Isordil Tembids, Isosorbide Dinitrate, Isosorbide Dinitrate LA, Sorbitrate, Sorbitrate SA, Pentaerythritol Tetranitrate, Peritrate, Peritrate SA, Erythrityl Tetranitrate, Cardilate, Isosorbide Dinitrate/Phenobarbital, Isordil w/PB.

Illegal drugs containing organic nitrates are: amyl nitrate or nitrite (also known by various other names, including “poppers”), butyl nitrate.

The History of Cialis

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The history of Cialis

Since the March 27th 1998 FDA approval of the prescription drug Viagra, Pfizer, enjoyed a five plus year monopoly of being the only prescription drug company that could distribute the erectile dysfunction drug Sildenafil Citrate. And as such sold over 1 billion dollars worth of the drug in just the first year of introduction. This finally changed on August 19, 2003 with the FDA approval of Levitra and November 21, 2003 FDA approval of Cialis.

The development of the impotence prescription drug Cialis has an interesting beginning (The History of Cialis). The drug company Icos actually began studies on a PDE5 enzyme inhibiter called IC351 in 1993. This is the process by which all erectile dysfunction drugs work. Interestingly enough, in 1994 scientist for Pfizer discovered that Sildenafil Citrate caused heart patients to get an erection during clinical studies of the heart medicine.

One can only assume that testing that was being conducted for the chemical compound IC351 was not being tested for erectile dysfunction. Little did they know that the compound that was similar in effect to Sildenafil Citrate, just one year later would be discovered as a potential impotence medication by another drug company, Pfizer.

The Bothell, Washington-based company, Icos, that began operations in 1990, received its first patent on IC351 in 1994. It is uncertain whether whether the patent was granted before or after the Pfizer discovery. Phase I clinical trials began in 1995. And after two years of testing, phase II clinical studies began. During this phase, 1997 marked the year that Icos conducted its first study in patients with erectile dysfunction. This phase lasted for two year up to the final third phase.

In 1998, Icos and Eli Lilly and Co. joined forces to commercialize the drug for the treatment of sexual dysfunction. Two years later the new company filed a new drug application with the U.S. Food and Drug Administration for IC351 and renamed the drug Cialis.

On May 2002 Lilly and Icos reported to the American Urological Association that Phase III test results for Cialis concluded that Cialis remained in the system and kept working for up to 36 hours. These findings were presented at the 97th Annual Meeting of the American Urological Association in Orlando, Florida.

That same year on November 2002, Cialis was approved in Europe. One year later Lilly and Icos finally won U.S. FDA approval for Cialis on November 21, 2003.

Tadalafil, brand name Cialis, has a distinct advantage over Viagra. Cialis drugs lasts up to 36 hour verses 4 hours for Viagra drugs. This can prove to be more appealing to most men and perhaps a better value. While Viagra enjoys better brand recognition Cialis will follow suit.

How does Cialis work?

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Cialis work

When a man is sexually stimulated, signals from the nervous system and the release of chemical messengers within the tissues of the penis allow him to have an erection.

One of these chemical messengers, called cyclic GMP, causes the blood vessels in the penis to widen by relaxing smooth muscle tissue. This results in more blood flow to the penis, making the penis larger and harder until full erection.

Cyclic GMP is normally regulated and constantly broken down by another chemical in the body called PDE-5. When there is more cyclic GMP than PDE-5, an erection results. Once the PDE-5 breaks down the cyclic GMP, the erection goes away.

Men with ED often cannot produce enough cyclic GMP. The little that is made is rapidly broken down by PDE-5, and blood flow is reduced, resulting in erectile failure.

Cialis drug is a PDE-5 inhibitor. It works by preventing the action of PDE-5, therefore stopping the breakdown of cyclic GMP.

This means that the blood vessels are kept dilated for longer, improving and maintaining blood flow to the penis, and therefore magnifying the natural erectile function.

* It is important to understand that taking Cialis will not just make you have a sudden or unexpected erection at inappropriate times. What happens after taking Cialis drugs is that, if you are not sexually stimulated, your body will not produce any Cyclic GMP and PDE-5, and without those present in your body, Canadian Cialis will have nothing to work on and will therefore remain inactive. Similarly, after sex, as sexual stimulation stops, your body will stop the production of Cyclic GMP and PDE-5, and your erection will go away. Cheap Cialis will remain in your system for its duration, so if you are stimulated while it’s still present in your body, it will help you have and keep an erection.

Other drugs that operate the same way as Cialis are Viagra and Levitra.

What causes ED (Erectile Dysfunction)?

erectile dysfunction

Erectile Dysfunction (ED) is the inability to get and maintain an erection of the penis for satisfactory sexual intercourse. In most cases, ED is a physical health problem, as opposed to psychological. It is usually caused by or associated with high blood pressure, high cholesterol, or diabetes, problems that are more often present as we get older.

Smoking, drinking too much alcohol, or stress, are also known to cause ED. canadian antibiotics

ED can happen to men of all ages. Whether your case is severe or mild, even if it only happens to you once in a while, or even if you can have an erection but not maintain it for a long time, Cialis drugs can help you get and keep a full and strong erection, regardless of your age.

Cialis (Tadalafil) is an effective treatment option for men who experience erectile dysfunction after having prostate surgery.

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About Cialis
myimg Tadalafil is an orally administered drug for treating impotence (erectile dysfunction), that initially was developed by the biotechnology company ICOS, and then developed and marketed world-wide as Cialis, by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialis tablets, in 5mg, 10mg, and 20mg doses, are yellow, film-coated, and almond-shaped.